Oxytocin receptor-deficient mice developed late-onset obesity

Yuki Takayanagi, Yoshiyuki Kasahara, Tatsushi Onaka, Nobuyuki Takahashi, Teruo Kawada, Katsuhiko Nishimori

Research output: Contribution to journalArticlepeer-review

177 Citations (Scopus)

Abstract

The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalNeuroReport
Volume19
Issue number9
DOIs
Publication statusPublished - 2008 Jun 11

Keywords

  • Brown adipose tissue
  • Cold exposure
  • Knockoutmouse
  • Obesity
  • Oxytocin receptor
  • Thermogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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