TY - JOUR
T1 - Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes
AU - Koakutsu, Tomoaki
AU - Nomura, Ryosuke
AU - Yamanouchi, Satoshi
AU - Kushimoto, Shigeki
AU - Itoi, Eiji
AU - Shinozawa, Yotaro
PY - 2013/3
Y1 - 2013/3
N2 - Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.
AB - Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.
KW - Antioxidant status
KW - Necrotizing soft tissue infection
KW - Oxygen free radical
UR - http://www.scopus.com/inward/record.url?scp=84873901143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873901143&partnerID=8YFLogxK
U2 - 10.3109/03009734.2012.733738
DO - 10.3109/03009734.2012.733738
M3 - Article
C2 - 23163625
AN - SCOPUS:84873901143
VL - 118
SP - 46
EP - 50
JO - Upsala Journal of Medical Sciences
JF - Upsala Journal of Medical Sciences
SN - 0300-9734
IS - 1
ER -