Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes

Tomoaki Koakutsu, Ryosuke Nomura, Satoshi Yamanouchi, Shigeki Kushimoto, Eiji Itoi, Yotaro Shinozawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Two cases of necrotizing soft tissue infection of the lower extremity were treated concurrently but independently. Multimodal therapy including hip joint disarticulation and hyperbaric oxygen therapy was administered, resulting in opposite outcomes: survival and death. Analysis of the relationships between patient outcome and time-course changes in serum diacron-reactive oxygen metabolites (d-ROMs; an index of oxidative stress), antioxidative potential, and cytokines revealed that serum d-ROMs levels decreased with time, but high serum levels of interleukin-10 (anti-inflammatory cytokine) persisted in the patient who died. These findings may reflect an immunosuppressive status unfavorable to infection prevention. Serum d-ROMs may be a prognostic predictor in necrotizing soft tissue infections.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalUpsala Journal of Medical Sciences
Volume118
Issue number1
DOIs
Publication statusPublished - 2013 Mar

Keywords

  • Antioxidant status
  • Necrotizing soft tissue infection
  • Oxygen free radical

ASJC Scopus subject areas

  • Medicine(all)

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