Oxidized LDL and expression of monocyte adhesion molecules

Toru Kita, Noriaki Kume, Kenji Ishii, Hisanori Horiuchi, Hidenori Arai, Masayuki Yokode

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalDiabetes Research and Clinical Practice
Volume45
Issue number2-3
DOIs
Publication statusPublished - 1999 Sep 1
Externally publishedYes

Keywords

  • Lox-1
  • Lysophosphatidylcholine
  • Monocyte adhesion molecules
  • Oxidized LDL

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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