Oxidized-LDL and atherosclerosis role of LOX-1

Toru Kita, Noriaki Kume, Masayuki Yokode, Kenji Ishii, Hidenori Arai, Hisanori Horiuchi, Hideaki Moriwaki, Manabu Minami, Hiroharu Kataoka, Yoshio Wakatsuki

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The accumulation of substantial numbers of monocyte/macrophages and activated T lymphocytes in focal areas of the arterial intima appears to be a hallmark of atherosclerosis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherosclerotic lipoproteins, such as oxidized LDL and remnant lipoproteins in diabetic and Type 3 hyperlipidemia, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF A and B chains. Recently, we identified the novel receptor for oxidized LDL, named LOX-1. We summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1, in terms of early stage atherogenesis.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume902
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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