Oxidized DJ-1 as a possible biomarker of Parkinson's disease

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Parkinson's disease is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at position 106, Cys-106, under oxidative stress. The critical role of Cys-106 in the biological function of DJ-1 has been demonstrated, and recent studies indicate that DJ-1 acts as a sensor of oxidative stress by regulating the gene expression of antioxidative defense. Specific antibodies against Cys-106-oxidized DJ-1 have been developed, and the generation of oxidized DJ-1 in cellular and animal models of Parkinson's disease has been investigated. This review focuses on the role of DJ-1 in antioxidative defense and the importance of oxidizable Cys-106 in its function. The signifi- cance of the identification of early-phase Parkinson's disease biomarkers and the nature of oxidized DJ-1 as a biomarker for Parkinson's disease are discussed here.

Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalJournal of Clinical Biochemistry and Nutrition
Volume54
Issue number3
DOIs
Publication statusPublished - 2014 May
Externally publishedYes

Keywords

  • Cysteine
  • DJ-1
  • Oxidative stress
  • Parkinson's disease
  • Sulfonic acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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