TY - JOUR
T1 - Oxidative stress more strongly induced by ortho- than para-quinoid polycyclic aromatic hydrocarbons in A549 cells
AU - Motoyama, Yumi
AU - Bekki, Kanae
AU - Sang, Woon Chung
AU - Tang, Ning
AU - Kameda, Takayuki
AU - Toriba, Akira
AU - Taguchi, Keiko
AU - Hayakawa, Kazuichi
PY - 2009/10
Y1 - 2009/10
N2 - The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2.
AB - The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2.
KW - Cytotoxicity
KW - Hydrogen peroxide
KW - Ortho-quinoid polycyclic aromatic hydrocarbon
KW - Oxidative stress
KW - Redox cycle
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U2 - 10.1248/jhs.55.845
DO - 10.1248/jhs.55.845
M3 - Article
AN - SCOPUS:70350241486
VL - 55
SP - 845
EP - 850
JO - Journal of Health Science
JF - Journal of Health Science
SN - 1344-9702
IS - 5
ER -