Oxidative stress more strongly induced by ortho- than para-quinoid polycyclic aromatic hydrocarbons in A549 cells

Yumi Motoyama, Kanae Bekki, Woon Chung Sang, Ning Tang, Takayuki Kameda, Akira Toriba, Keiko Taguchi, Kazuichi Hayakawa

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalJournal of Health Science
Volume55
Issue number5
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • Cytotoxicity
  • Hydrogen peroxide
  • Ortho-quinoid polycyclic aromatic hydrocarbon
  • Oxidative stress
  • Redox cycle

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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