Oxidative damage in Alzheimer's disease: The metabolic dimension

George Perry, Akihiko Nunomura, Keisuke Hirai, Atsushi Takeda, Gjumrakch Aliev, Mark A. Smith

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Cell bodies of neurons at risk of death in Alzheimer disease have increased lipid peroxidation, nitration, free carbonyls, and nucleic acid oxidation. These oxidative changes are uniform among neurons and are seen whether or not the neurons display neurofibrillary tangles and, in fact, are acutally reduced in the latter case. In consideration of this localization of damage, in this review, we provide a summary of recent work demonstrating some key abnormalities that may initiate and promote neuronal oxidatave damage. Copyright (C) 2000 ISDN.

Original languageEnglish
Pages (from-to)417-421
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Volume18
Issue number4-5
DOIs
Publication statusPublished - 2000 Jul 1

Keywords

  • Alzheimer disease
  • Amyloid-β
  • Lipid peroxidation
  • Mitochondria
  • Neurofibrillary tangle
  • Oxidative damage

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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