Oxazepine synthesis by copper-catalyzed intermolecular cascade reactions between O-propargylic oximes and dipolarophiles

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30 Citations (Scopus)

Abstract

Three-step cascade: Oxazepine derivatives were efficiently prepared from O-propargylic oximes and dipolarophiles through copper-catalyzed cascade reactions which proceed through a 2,3-rearrangement, [3+2] cycloaddition, and subsequent 1,3-oxygen rearrangement. The process involves the cleavage of C-O and N-O bonds.

Original languageEnglish
Pages (from-to)7536-7539
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number29
DOIs
Publication statusPublished - 2013 Jul 15

Keywords

  • copper
  • cycloaddition
  • heterocycles
  • rearrangement
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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