Abstract
The human salivary amylase gene (amy1), consisting of eleven exons, is expressed in the salivary gland and in some amylase-producing tumors. Its uppermost exon and the following intron, along with the 5′-flanking region of this gene, are shown to be superimposed with a γ-actin pseudogene sequence, a portion of which is transcribed into salivary amylase mRNA and another portion of which serves as a promoter for the amy1 gene. In the further upstream region, the γ-actin pseudogene sequence is interrupted by a human endogenous retroviral nucleotide sequence.
| Original language | English |
|---|---|
| Pages (from-to) | 229-235 |
| Number of pages | 7 |
| Journal | Gene |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1988 Feb 29 |
Keywords
- (Recombinant DNA
- exon
- gene evolution
- intron
- tumors)
- upstream control region
- λ Charon vectors
ASJC Scopus subject areas
- Genetics
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Cite this
Emi, M., Horii, A., Tomita, N., Nishide, T., Ogawa, M., Mori, T., & Matsubar, K. (1988). Overlapping two genes in human DNA: a salivary amylase gene overlaps with a gamma-actin pseudogene that carries an integrated human endogenous retroviral DNA. Gene, 62(2), 229-235. https://doi.org/10.1016/0378-1119(88)90561-6