Overlapping two genes in human DNA: a salivary amylase gene overlaps with a gamma-actin pseudogene that carries an integrated human endogenous retroviral DNA

Mitsuru Emi, Akira Horii, Naohiro Tomita, Takahiro Nishide, Michio Ogawa, Takesada Mori, Kenichi Matsubar

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The human salivary amylase gene (amy1), consisting of eleven exons, is expressed in the salivary gland and in some amylase-producing tumors. Its uppermost exon and the following intron, along with the 5′-flanking region of this gene, are shown to be superimposed with a γ-actin pseudogene sequence, a portion of which is transcribed into salivary amylase mRNA and another portion of which serves as a promoter for the amy1 gene. In the further upstream region, the γ-actin pseudogene sequence is interrupted by a human endogenous retroviral nucleotide sequence.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalGene
Volume62
Issue number2
DOIs
Publication statusPublished - 1988 Feb 29

Keywords

  • (Recombinant DNA
  • exon
  • gene evolution
  • intron
  • tumors)
  • upstream control region
  • λ Charon vectors

ASJC Scopus subject areas

  • Genetics

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