TY - JOUR
T1 - Overlapping two genes in human DNA
T2 - a salivary amylase gene overlaps with a gamma-actin pseudogene that carries an integrated human endogenous retroviral DNA
AU - Emi, Mitsuru
AU - Horii, Akira
AU - Tomita, Naohiro
AU - Nishide, Takahiro
AU - Ogawa, Michio
AU - Mori, Takesada
AU - Matsubar, Kenichi
PY - 1988/2/29
Y1 - 1988/2/29
N2 - The human salivary amylase gene (amy1), consisting of eleven exons, is expressed in the salivary gland and in some amylase-producing tumors. Its uppermost exon and the following intron, along with the 5′-flanking region of this gene, are shown to be superimposed with a γ-actin pseudogene sequence, a portion of which is transcribed into salivary amylase mRNA and another portion of which serves as a promoter for the amy1 gene. In the further upstream region, the γ-actin pseudogene sequence is interrupted by a human endogenous retroviral nucleotide sequence.
AB - The human salivary amylase gene (amy1), consisting of eleven exons, is expressed in the salivary gland and in some amylase-producing tumors. Its uppermost exon and the following intron, along with the 5′-flanking region of this gene, are shown to be superimposed with a γ-actin pseudogene sequence, a portion of which is transcribed into salivary amylase mRNA and another portion of which serves as a promoter for the amy1 gene. In the further upstream region, the γ-actin pseudogene sequence is interrupted by a human endogenous retroviral nucleotide sequence.
KW - (Recombinant DNA
KW - exon
KW - gene evolution
KW - intron
KW - tumors)
KW - upstream control region
KW - λ Charon vectors
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U2 - 10.1016/0378-1119(88)90561-6
DO - 10.1016/0378-1119(88)90561-6
M3 - Article
C2 - 2452768
AN - SCOPUS:0023869845
VL - 62
SP - 229
EP - 235
JO - Gene
JF - Gene
SN - 0378-1119
IS - 2
ER -