Abstract
The clinical picture of IgG4-related disease (IgG4-RD) is diverse because various organs can be affected. We describe the case of a 56-year-old man with acute renal failure and tuberoinfundibular hypophysitis due to IgG4-RD. Steroid therapy lowered the serum IgG4 level and ameliorated renal dysfunction, bilateral hydronephrosis and retroperitoneal fibrosis. However, polyuria from post-obstructive diuresis and unmasked central diabetes insipidus ensued. The patient’s polyuria continued despite the administration of a therapeutic dose of glucocorticoid; the patient’s pituitary swelling and anterior pituitary dysfunction were partially ameliorated. The pituitary swelling recurred seven months later. In patients with IgG4-RD, the manifestation of polyuria after steroid therapy should prompt suspicion of post-obstructive diuresis and the unmasking of central diabetes insipidus.
Original language | English |
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Pages (from-to) | 47-53 |
Number of pages | 7 |
Journal | Internal Medicine |
Volume | 56 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Diabetes insipidus
- IgG4-related disease
- Pituitary
- Polyuria
- Prednisolone
- Retroperitoneal fibrosis
ASJC Scopus subject areas
- Internal Medicine