Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae

Tsutomu Takahashi, Shingo Nakashima, Takuro Masuda, Shigehiro Yoneda, Gi Wook Hwang, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

To elucidate the mechanisms underlying adriamycin resistance, adriamycin resistancerelated genes were explored using the budding yeast Saccharomyces cerevisiae as a useful eukaryotic model. The CLN1 and CLN2 genes, encoding G1 cyclin, and the ERG13 gene, encoding 3-hydroxy-3- methylglutaryl-coenzyme A (HMG-CoA) synthase, were identified.

Original languageEnglish
Pages (from-to)855-857
Number of pages3
JournalJournal of Toxicological Sciences
Volume36
Issue number6
DOIs
Publication statusPublished - 2011

Keywords

  • Adriamycin
  • G1 cyclin
  • HMG-CoA synthase
  • Resistance
  • Yeast

ASJC Scopus subject areas

  • Toxicology

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