TY - JOUR
T1 - Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human
AU - Morito, Naoki
AU - Yoh, Keigyou
AU - Fujioka, Yuki
AU - Nakano, Takako
AU - Shimohata, Homare
AU - Hashimoto, Yuko
AU - Yamada, Akiko
AU - Maeda, Atsuko
AU - Matsuno, Fumihiko
AU - Hata, Hiroyuki
AU - Suzuki, Atsushi
AU - Imagawa, Shigehiko
AU - Mitsuya, Hiroaki
AU - Esumi, Hiroyasu
AU - Koyama, Akio
AU - Yamamoto, Masayuki
AU - Mori, Naoyoshi
AU - Takahashi, Satoru
PY - 2006/1/15
Y1 - 2006/1/15
N2 - c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin β7, and AKK5 were upregulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin β7, might be downstream target genes of c-Maf leading to malignant transformation.
AB - c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin β7, and AKK5 were upregulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin β7, might be downstream target genes of c-Maf leading to malignant transformation.
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U2 - 10.1158/0008-5472.CAN-05-2154
DO - 10.1158/0008-5472.CAN-05-2154
M3 - Article
C2 - 16424013
AN - SCOPUS:31544476523
VL - 66
SP - 812
EP - 819
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 2
ER -