Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human

Naoki Morito, Keigyou Yoh, Yuki Fujioka, Takako Nakano, Homare Shimohata, Yuko Hashimoto, Akiko Yamada, Atsuko Maeda, Fumihiko Matsuno, Hiroyuki Hata, Atsushi Suzuki, Shigehiko Imagawa, Hiroaki Mitsuya, Hiroyasu Esumi, Akio Koyama, Masayuki Yamamoto, Naoyoshi Mori, Satoru Takahashi

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

c-Maf translocation or overexpression has been observed in human multiple myeloma. Although c-maf might function as an oncogene in multiple myeloma, a role for this gene in other cancers has not been shown. In this study, we have found that mice transgenic for c-Maf whose expression was direct to the T-cell compartment developed T-cell lymphoma. Moreover, we showed that cyclin D2, integrin β7, and AKK5 were upregulated in c-Maf transgenic lymphoma cells. Furthermore, 60% of human T-cell lymphomas (11 of 18 cases), classified as angioimmunoblastic T-cell lymphoma, were found to express c-Maf. These results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin β7, might be downstream target genes of c-Maf leading to malignant transformation.

Original languageEnglish
Pages (from-to)812-819
Number of pages8
JournalCancer Research
Volume66
Issue number2
DOIs
Publication statusPublished - 2006 Jan 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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