Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: Case report and literature review

Jun Ichi Akahira, Kiyoshi Ito, Shyuichi Kosuge, Ryo Konno, Shinji Sato, Akira Yajima, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A case of ovarian mixed germ cell tumor in a 44-year-old woman was examined. The tumor was well circumscribed, measured 15 x 11 x 10 cm and appeared solid and partly cystic on the cut surface. Light microscopic examinations revealed that the tumor was composed of four different neoplastic germ cell elements, intermingled with each other. They are: (i) choriocarcinoma, immunohistochemically positive for human placental lactogen (hPL) and human chorionic gonadotropin (hCG); (ii) dysgerminoma, positive for placental alkaline phosphatase; (iii) endodermal sinus tumor positive for (α-fetoprotein (AFP); and (iv) mature teratoma. Among these histological types, dysgerminoma occupied more than 50% of the neoplasm. The patient was diagnosed as a stage la ovarian mixed germ cell tumor and was subsequently treated with chemotherapy. A second-look laparotomy after completion of chemotherapy revealed no residual tumors in the abdomen and the patient is alive and well 15 months after operation. This is the fourth reported case of ovarian mixed germ cell tumor arising in patients over 40 years old.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalPathology international
Volume48
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • Choriocarcinoma
  • Dysgerminoma
  • Endodermal sinus tumor
  • Germ cell tumor
  • Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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