Ovarian metastasis in carcinoma of the uterine cervix

Muneaki Shimada, Junzo Kigawa, Ryuichiro Nishimura, Satoshi Yamaguchi, Kazuo Kuzuya, Toru Nakanishi, Mitsuaki Suzuki, Tsunekazu Kita, Tsuyoshi Iwasaka, Naoki Terakawa

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

Background.: The present study was conducted to determine the frequency and clinicopathological features of ovarian metastasis in a large population of patients with stage Ib-IIb cervical cancer. Methods.: The study population consisted of 3471 patients with stage Ib to IIb cervical cancer who underwent radical hysterectomy, including pelvic lymphadenectomy and bilateral salpingo-oophorectomy, at our six institutions between 1981 and 2000. To our knowledge, this study is the largest review of patients with ovarian metastasis from cervical cancer. We reviewed the patients' medical records to determine clinicopathological features. Results.: Fifty-two patients (1.50%) had ovarian metastases: 6 in stage Ib1, 12 in stage Ib2, 5 in stage IIa, and 29 in stage IIb. The mean age of patients with ovarian metastasis was 49.9 years (range: 29-73 years). The incidence of ovarian metastasis in patients with cervical cancer was 0.22% for stage Ib, 0.75% for stage IIa, and 2.17% for stage IIb with squamous cell carcinoma, and 3.72%, 5.26%, and 9.85%, respectively, in adenocarcinoma. Ovarian metastasis occurred more frequently among patients with adenocarcinoma than among those with squamous cell carcinoma (5.31% vs. 0.79%). Outcome for patients with ovarian metastasis was very poor and not related to FIGO stage and histological type. The presence of ovarian metastasis did not correlate with lymph node involvement or parametrial invasion. Conclusion.: Study results indicate that ovaries can be preserved in patients with stage Ib-IIa squamous cell carcinoma but removed in all patients with adenocarcinoma.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalGynecologic Oncology
Volume101
Issue number2
Publication statusPublished - 2006 May
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Ovarian metastasis
  • Radical hysterectomy
  • Squamous cell carcinoma
  • Uterine cervical cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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