Outpatient cardiac rehabilitation suppresses deterioration of renal function in patients ≥75 years of age with heart disease

Yuichiro Sasamoto, Noriko Endo, Kohko Kanazawa, Taeko Utsumi, Tomomi Takahashi, Yosuke Endo, Makoto Nanba, Hiroto Takeda, Tomohiro Takano, Koki Takahashi, Masahiro Tanji, Masahiro Kohzuki

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This study investigated the effect of outpatient cardiac rehabilitation (OCR) and physical activity on the estimated glomerular filtration rate based on serum cystatin C (eGFRcys) in patients with heart disease (HD) aged ≥75 years. Methods and Results: This non-randomized prospective intervention study involved 136 patients (non-OCR group, n=66; OCR group, n=70), 55 of whom were aged ≥75 years (non-OCR group, n=29; OCR group, n=26). Renal function (eGFRcys) was evaluated at discharge and 3 months thereafter. A linear mixed model (LMM) was used to assess changes in renal function over time. The hospital readmission rate within 3 months after discharge was also evaluated. LMM analysis showed that the change in eGFRcys was -2.27 and +0.48mL/min/1.73m2 in the non-OCR and OCR groups, respectively (F=2.960, P=0.022). Further, among patients aged ≥75 years in the non-OCR and OCR groups, the change in eGFRcys was -3.83 and -1.08mL/min/1.73m2, respectively (F=2.719, P=0.039). The proportion of patients aged ≥75 years who were rehospitalized due to exacerbation of HD was 16.9% (n=10) and 6.7% (n=2) in the non-OCR and OCR groups, respectively. Conclusions: Among patients with HD aged ≥75 years, participation in OCR reduces the decline in renal function and hospital readmission rates.

Original languageEnglish
Pages (from-to)612-622
Number of pages11
JournalCirculation Journal
Volume85
Issue number5
DOIs
Publication statusPublished - 2021 Apr

Keywords

  • Cystatin C
  • Glomerular filtration rate
  • Kidney disease
  • Patient readmission
  • Physical activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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