Outcomes after resection of occupational cholangiocarcinoma

Shoji Kubo, Shigekazu Takemura, Shogo Tanaka, Hiroji Shinkawa, Masahiko Kinoshita, Genya Hamano, Tokuji Ito, Masaki Koda, Takanori Aota, Takatsugu Yamamoto, Hiroaki Terajima, Gorou Tachiyama, Terumasa Yamada, Shoji Nakamori, Akira Arimoto, Masahiro Fujikawa, Yoshito Tomimaru, Yasuhiko Sugawara, Kei Nakagawa, Michiaki UnnoToru Mizuguchi, Kenji Takenaka, Koichi Kimura, Ken Shirabe, Akio Saiura, Katsuhiko Uesaka, Hiroki Taniguchi, Akira Fukuda, Ja Mun Chong, Yuko Kuwae, Masahiko Ohsawa, Yasunori Sato, Yasuni Nakanuma

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane is recognized as occupational cholangiocarcinoma. The aim of this study was to investigate the outcomes after resection of occupational cholangiocarcinoma to establish a treatment strategy for this disease. Methods: Clinicopathological findings and outcomes after surgical intervention in 20 patients with occupational cholangiocarcinoma were investigated. Results: Of 20 the patients, curative resection was performed in 16 patients. Three patients underwent radiation at the stump of the bile ducts. Adjuvant chemotherapy was performed in 12 patients. Biliary intraepithelial neoplasia, intraductal papillary neoplasm of the bile duct, and/or chronic bile duct injury was detected in most subjects. Intraabdominal infection developed after surgery in nine patients. Cholangiocarcinoma recurred in 12 of the 20 patients. The recurrent tumors in five patients developed at a different part of the bile duct from the primary tumor and a second resection was performed in four of these five patients. Conclusions: The incidence of postoperative complications including intraabdominal infection was high in patients with occupational cholangiocarcinoma. Multicentric recurrence occurred not infrequently after surgery because the bile ducts had a high potential for the development of carcinoma. The aggressive treatment including second resection for the multicentric recurrence appeared to be effective.

Original languageEnglish
Pages (from-to)556-564
Number of pages9
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume23
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • Biliary intraepithelial neoplasia
  • Intraductal papillary neoplasm of the bile duct
  • Multicentric recurrence
  • Occupational cholangiocarcinoma
  • Postoperative complications

ASJC Scopus subject areas

  • Medicine(all)

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    Kubo, S., Takemura, S., Tanaka, S., Shinkawa, H., Kinoshita, M., Hamano, G., Ito, T., Koda, M., Aota, T., Yamamoto, T., Terajima, H., Tachiyama, G., Yamada, T., Nakamori, S., Arimoto, A., Fujikawa, M., Tomimaru, Y., Sugawara, Y., Nakagawa, K., ... Nakanuma, Y. (2016). Outcomes after resection of occupational cholangiocarcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 23(9), 556-564. https://doi.org/10.1002/jhbp.373