Ostiomeatal complex and clinical efficacy of macrolides

K. Ikeda, H. Suzuki, T. Oshima, N. Tanno, A. Shimomura

Research output: Contribution to journalArticlepeer-review


Clinical efficacy of macrolide antibiotics in the treatment of chronic sinusitis was summarized. Based on the basic studies, macrolides significantly inhibited the adhesion of Pseudomonas aeruginosa and Branhamella catarrhalis to human nasal epithelial cells, the Cl- secretion from the submucosal nasal gland acinar cells, and the production of IL-8 in patients with chronic sinusitis, suggesting the reversible recovery of mucociliary function. The mucociliary clearance of the maxillary sinus using radionuclide technique was restored by the removal of obstructive lesion of the ostiomeatal complex (OMC). Non-responders to macrolide treatment tended to show severe obstruction of the OMC. Thus, macrolide treatment for chronic sinusitis requires patency between nasal cavity and paranasal sinuses via OMC, in order to the restoration of mucociliary clearance.

Original languageEnglish
Pages (from-to)83-84
Number of pages2
JournalOto-Rhino-Laryngology Tokyo
Issue number2 SUPPL. 1
Publication statusPublished - 1996


  • chronic sinusitis
  • macrolide
  • mucociliary function
  • ostiomeatal complex

ASJC Scopus subject areas

  • Otorhinolaryngology


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