Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation

Rieko Ajima, Toru Akiyama, Michihiko Usui, Mitsuhiro Yoneda, Yutaka Yoshida, Takahisa Nakamura, Osamu Minowa, Masaki Noda, Sakae Tanaka, Tetsuo Noda, Tadashi Yamamoto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Mice lacking tob2, a member of the antiproliferative family genes, had decreased bone mass, and the number of osteoclasts differentiated from bone marrow cells was increased. Overexpression of Tob2 in stromal cells repressed vitamin D3-induced osteoclasts formation. Furthermore, expression of RANKL mRNA in stromal cells was increased in the absence of Tob2 and decreased in the presence of Tob2. Tob2 interacted with vitamin D3 receptor (VDR), which suggests its involvement in vitamin D3 receptor-mediated regulation of transcription. Because VDR regulates RANKL expression, our data suggest that Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with VDR.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalFEBS Letters
Volume582
Issue number9
DOIs
Publication statusPublished - 2008 Apr 16
Externally publishedYes

Keywords

  • Bone mass
  • Gene targeting
  • Osteoclast
  • Vitamin D
  • tob Family

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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