Osteogenic response under the periosteum by magnesium implantation in rat tibia

Odashima Kenji, Shimizu Yoshinaka, Sano Yuya, Yamamoto Akiko, Mukai Toshiji, Takada Yukyo, Yanagisawa Yuta, Imai Yoshimichi, Tetsu Takahashi, Kumamoto Hiroyuki

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1 Citation (Scopus)


This study was designed to examine osteoconductive effects of Mg in rats tibia. The animals were sacrificed after 1, 2, and 8 weeks. The elemental analysis was performed using SEM/EDX at week 1. Following X-ray micrography at weeks 2 and 8, samples were embedded in paraffin. The expression of osteocalcin was observed by immunohistochemical staining. The element concentrations of fibrous capsules around the specimens were also measured by ICP-MS. The concentrations of Ca and P on the surface of the Mg specimen increased in SEM/EDX. The tissue specimen showed new bone formation on the bone surface near the implanted area. The concentrations of Mg, Ca, and P were high in the fibrous capsules surrounding Mg. Implantation induced differentiation of osteoblasts, and this process was considered to be associated with new bone formation. Induction of cell differentiation may be influenced by corrosion products in addition to corroding magnesium.

Original languageEnglish
Article numberdmj/2020-011
Pages (from-to)498-507
Number of pages10
JournalDental materials journal
Issue number2
Publication statusPublished - 2021


  • Biodegradation
  • ICP-MS
  • Magnesium
  • Osteogenic

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)


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