Osteogenesis mechanism based on kinetic theory

Toshimitsu Yokobori

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    In our earlier studies, we considered osteogenesis to be a nucleation mechanism accompanied by preliminary diffusion and showed the optimum mechanical conditions for promoting this ionic diffusion. In this study, we performed an analysis of the nucleation mechanism of hydroxyapatite (HA) in areas with h high concentration of transported Ca and PO4 ions in the pore region along the collagen alignment. We derived the equation of the HA nucleation rate as a function of hydrostatic tensile stress, σ(P) and surface energy change (γ - 1/4 ), where 1/4 is the surface energy of the HA particle and λ is the decreasing factor of λ during HA nucleation. λ is thus related to the effect of chemical and electric stimulations. Finally, we formulated a unified equation of the nucleation rate of HA, which consists of ionic diffussion and HA nucleation processes.

    Original languageEnglish
    Pages (from-to)253-257
    Number of pages5
    JournalBio-medical materials and engineering
    Issue number5-6
    Publication statusPublished - 1998 Dec 1


    • Diffusion
    • Hydroxyapatite
    • Mineralization
    • Nucleation
    • Osteogenesis

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering


    Dive into the research topics of 'Osteogenesis mechanism based on kinetic theory'. Together they form a unique fingerprint.

    Cite this