Oseltamivir enhances hippocampal network synchronization

Atsushi Usami; Takuya Sasaki; Nobuhiro Satoh; Takahiro Akiba; Satoshi Yokoshima; Tohru Fukuyama; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Norio Matsuki; Yuji Ikegaya

doi:10.1254/jphs.SC0070467

Oseltamivir enhances hippocampal network synchronization

Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation. Supplementary Fig. and movie: available only at http:/ /dx.doi.org/10.1254/jphs.SC0070467.

Original language	English
Pages (from-to)	659-662
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	106
Issue number	4
DOIs	https://doi.org/10.1254/jphs.SC0070467
Publication status	Published - 2008
Externally published	Yes

Keywords

Functional multineuron calcium imaging
Network excitability
Oseltamivir

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1254/jphs.SC0070467

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title = "Oseltamivir enhances hippocampal network synchronization",

abstract = "Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation. Supplementary Fig. and movie: available only at http:/ /dx.doi.org/10.1254/jphs.SC0070467.",

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author = "Atsushi Usami and Takuya Sasaki and Nobuhiro Satoh and Takahiro Akiba and Satoshi Yokoshima and Tohru Fukuyama and Kenzo Yamatsugu and Motomu Kanai and Masakatsu Shibasaki and Norio Matsuki and Yuji Ikegaya",

year = "2008",

doi = "10.1254/jphs.SC0070467",

language = "English",

volume = "106",

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T1 - Oseltamivir enhances hippocampal network synchronization

AU - Usami, Atsushi

AU - Sasaki, Takuya

AU - Satoh, Nobuhiro

AU - Akiba, Takahiro

AU - Yokoshima, Satoshi

AU - Fukuyama, Tohru

AU - Yamatsugu, Kenzo

AU - Kanai, Motomu

AU - Shibasaki, Masakatsu

AU - Matsuki, Norio

AU - Ikegaya, Yuji

PY - 2008

Y1 - 2008

N2 - Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation. Supplementary Fig. and movie: available only at http:/ /dx.doi.org/10.1254/jphs.SC0070467.

AB - Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation. Supplementary Fig. and movie: available only at http:/ /dx.doi.org/10.1254/jphs.SC0070467.

KW - Functional multineuron calcium imaging

KW - Network excitability

KW - Oseltamivir

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JF - Journal of Pharmacological Sciences

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Oseltamivir enhances hippocampal network synchronization

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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