Ortho-C-H Benzylation of Aryl Imines with Benzyl Phosphates under Cobalt-Pyphos Catalysis

Wengang Xu, Rupankar Paira, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

Abstract

Ortho-C-H benzylation of aryl ketimines with benzyl phosphates is achieved with the aid of a catalytic system consisting of a cobalt(II) salt, a phosphine/pyridine bidentate ligand, and a Grignard reagent under room-temperature conditions, affording a variety of diarylmethanes bearing o-acetyl or -acyl groups in moderate to good yields. Owing to the versatility of the o-acetyl group, the reaction opens useful synthetic routes to polycyclic compounds such as unsymmetrical anthracene, anthracenone, and anthraquinone derivatives.

Original languageEnglish
Pages (from-to)4192-4195
Number of pages4
JournalOrganic letters
Volume17
Issue number17
DOIs
Publication statusPublished - 2015 Aug 25
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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