Ornithine decarboxylase gene is a positional candidate gene affecting growth and carcass traits in F2 intercross chickens

Y. Uemoto, S. Sato, T. Ohtake, S. Sato, Y. Okumura, E. Kobayashi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The ornithine decarboxylase (ODC) gene is a candidate gene for growth and carcass traits. It is located on chicken chromosome 3 in a region where QTL for growth and carcass traits have previously been detected in the F2 population. The objectives of this study were to identify polymorphisms of the ODC gene in an F2 resource population and to examine the effects of these ODC polymorphisms on growth and carcass traits. The F2 resource population was obtained by crossing a Shamo male and White Plymouth Rock females. The F2 population was then measured for growth and carcass traits and used for positional candidate gene analysis. A total of 6 novel SNP and a novel indel mutation were identified in the parental population. Three SNP (g.-638A> G, g.-465C>T, and g.-353C>T) and a 4-bp indel mutation (g.-633_-632ins) in the promoter region of the ODC gene were identified in the parental population, and 2 haplotypes composed of these mutations were segregated in the parental population. A QTL analysis was performed, and the QTL for some growth and carcass traits were detected at a significant level and on a similar position to the ODC gene. Significant associations were found between hap-lotypes in the promoter region of the ODC gene and these traits in the F2 population, and the effect of hap-lotype on BW at 9 wk of age was the most significant. The haplotypes of the ODC gene found in this study might help in understanding the genetic structure of growth and carcass traits and in improving these traits directly by MAS. Therefore, further functional studies are necessary to evaluate the effects of promoter mutations at a molecular level.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalPoultry science
Volume90
Issue number1
DOIs
Publication statusPublished - 2011 Jan

Keywords

  • Carcass trait
  • Chicken
  • Growth trait
  • Ornithine decarboxylase gene
  • Positional candidate gene

ASJC Scopus subject areas

  • Animal Science and Zoology

Fingerprint Dive into the research topics of 'Ornithine decarboxylase gene is a positional candidate gene affecting growth and carcass traits in F<sub>2</sub> intercross chickens'. Together they form a unique fingerprint.

Cite this