Origin of the Rhythmical Fluctuations in the Animal Without a Natural Heartbeat

Tomoyuki Yambe, Shin‐ichi ‐i Nitta, Taro Sonobe, Shigeru Naganuma, Yoshito Kakinuma, Shin‐ichi ‐i Kobayashi, Shunsuke Nanka, Noboru Ohsawa, Hiroshi Akiho, Motonao Tanaka, Takeo Fukuju, Makoto Miura, Naoki Uchida, Naoshi Sato, Hitoshi Mohri, Satoshi Koide, Ken‐ichi ‐i Abe, Hiroshi Takeda, Makoto Yoshizawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Abstract: In order to analyze the origin of the rhythmical fluctuations in the cardiovascular system, an artificial heart, which does not have rhythmical periodicities such as altering heart rate and cardiac function, was utilized in chronic animal experiments with adult goats. Two pneumatically actuated ventricular assist devices were implanted as a total biventricular bypass under general anesthesia, and then the natural heart was electrically fibrillated to constitute the biventricular bypass type of complete prosthetic circulation model. All hemodynamic data were recorded under awake conditions and were calculated in the computer system by spectral analysis methods. In the power spectrum of the arterial blood pressure of the animal with the artificial heart, the Mayer wave peak and respiratory wave peak were clearly observed, and spectral analysis including the coherence function suggests that the Mayer waves originated from the peripheral vascular resistance and the respiratory waves probably originated from the periodicities of the pulmonary circulation. These fluctuations in the circulatory system influenced the arterial baroreflex system and transfer to the sympathetic outflow through the central baroreflex system, which suggests that rhythmical fluctuations in hemodynamic parameters originate at least in part from these vascular periodicities.

Original languageEnglish
Pages (from-to)1017-1021
Number of pages5
JournalArtificial Organs
Volume17
Issue number12
DOIs
Publication statusPublished - 1993 Dec

Keywords

  • Artificial heart
  • Coherence function
  • Fluctuation
  • Mayer waves
  • Respiratory waves
  • Spectral analysis

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Yambe, T., Nitta, S. ., Sonobe, T., Naganuma, S., Kakinuma, Y., Kobayashi, S. ., Nanka, S., Ohsawa, N., Akiho, H., Tanaka, M., Fukuju, T., Miura, M., Uchida, N., Sato, N., Mohri, H., Koide, S., Abe, K. ., Takeda, H., & Yoshizawa, M. (1993). Origin of the Rhythmical Fluctuations in the Animal Without a Natural Heartbeat. Artificial Organs, 17(12), 1017-1021. https://doi.org/10.1111/j.1525-1594.1993.tb03184.x