A resin-supported N-terminal prolyl peptide having a β-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry