Organocatalytic asymmetric transfer hydrogenation in aqueous media using resin-supported peptide having a polyleucine tether

Kengo Akagawa, Hajime Akabane, Seiji Sakamoto, Kazuaki Kudo

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

A resin-supported N-terminal prolyl peptide having a β-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.

Original languageEnglish
Pages (from-to)2035-2037
Number of pages3
JournalOrganic letters
Volume10
Issue number10
DOIs
Publication statusPublished - 2008 May 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Organocatalytic asymmetric transfer hydrogenation in aqueous media using resin-supported peptide having a polyleucine tether'. Together they form a unique fingerprint.

Cite this