Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes

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11 Citations (Scopus)


We report that the organic superbase t-Bu-P4 efficiently catalyzes the amination of methoxy(hetero)arenes with amine nucleophiles such as aniline, indoline, and aminopyridine derivatives. This catalytic reaction is effective for the transformation of electron-deficient methoxyarenes possessing diverse functionalities (carbonyl, cyano, nitro, and halogen) as well as methoxyheteroarenes, including pyrazine, quinoline, isoquinoline, and pyridine derivatives. Intramolecular reactions provide six- and seven-membered ring cyclic amine products.

Original languageEnglish
Pages (from-to)5505-5508
Number of pages4
JournalOrganic letters
Issue number14
Publication statusPublished - 2019 Jul 2

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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