Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Chikashi Kanazawa; Masahiro Terada

doi:10.1016/j.tetlet.2006.12.015

Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Chikashi Kanazawa, Masahiro Terada

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

Original language	English
Pages (from-to)	933-935
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	6
DOIs	https://doi.org/10.1016/j.tetlet.2006.12.015
Publication status	Published - 2007 Feb 5

Keywords

Intramolecular cyclization
Organic-base
Phthalide
Regioselective

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tetlet.2006.12.015

Cite this

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title = "Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction",

abstract = "The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.",

keywords = "Intramolecular cyclization, Organic-base, Phthalide, Regioselective",

author = "Chikashi Kanazawa and Masahiro Terada",

year = "2007",

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AU - Kanazawa, Chikashi

AU - Terada, Masahiro

PY - 2007/2/5

Y1 - 2007/2/5

N2 - The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

AB - The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

KW - Intramolecular cyclization

KW - Organic-base

KW - Phthalide

KW - Regioselective

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Abstract

Keywords

ASJC Scopus subject areas

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