Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

Chikashi Kanazawa, Masahiro Terada

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic acid produces the corresponding phthalide regioselectively in good to excellent yields. The method provides a practical access to the phthalides, an important class of biologically active molecules.

Original languageEnglish
Pages (from-to)933-935
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number6
DOIs
Publication statusPublished - 2007 Feb 5

Keywords

  • Intramolecular cyclization
  • Organic-base
  • Phthalide
  • Regioselective

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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