Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey

Hiroko Akamatsu, Katsumasa Nakamura, Takeshi Ebara, Koji Inaba, Satoshi Itasaka, Keiichi Jingu, Yasuhiro Kosaka, Taro Murai, Kenji Nagata, Toshinori Soejima, Shigeo Takahashi, Tatsuya Toyoda, Shinichiro Toyoshima, Kenji Nemoto, Tetsuo Akimoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Small cell carcinoma of the bladder is extremely rare, accounting for <1% of all malignant tumours in the urinary tract. Thus, no standard therapy modality for this malignancy has been established. This study aimed to retrospectively analyse the clinical outcomes associated with definitive radiotherapy for small cell carcinoma of the bladder. A questionnaire-based survey of patients with pathologically proven small cell carcinoma of the bladder treated with definitive radiation therapy between 1990 and 2010 was conducted by the Japanese Radiation Oncology Study Group. The clinical records of 12 eligible patients were collected from nine institutions. The median age of the patients was 70.5 years (range: 44-87 years), and the median follow-up period was 27.3 months (range: 3.3-117.8 months). The median prescribed dose was 60 Gy (range: 50.0-61.0 Gy), and a median of 2.0 Gy (range: 1.2-2.0 Gy) was administered per fraction. Systemic chemotherapy combined with radiotherapy was performed in eight cases (66.7%). The 3- and 5-year overall survival rates were 50.0% and 33.3%, respectively. And the 3- and 5-year local control rates were 66.7% and 55.6%, respectively. Chemotherapy significantly improved overall survival and relapse-free survival (P = 0.006 and 0.001, respectively). No serious adverse events occurred in the observation period. All patients who achieved local control maintained functional bladders. In conclusion, radiotherapy is a potential local treatment option and has an important role in maintaining quality of life. Systemic chemotherapy combined with local radiotherapy seems to be effective in improving survival.

Original languageEnglish
Pages (from-to)509-516
Number of pages8
JournalJournal of radiation research
Volume60
Issue number4
DOIs
Publication statusPublished - 2019 Jul 1
Externally publishedYes

Keywords

  • bladder
  • bladder-sparing
  • extrapulmonary
  • radiotherapy
  • small cell carcinoma

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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