TY - JOUR
T1 - Organ blood flow in response to infusion of arginine vasopressin in premature fetal sheep
AU - Watanabe, Shimpei
AU - Matsuda, Tadashi
AU - Hanita, Takushi
AU - Ikeda, Hideyuki
AU - Koshinami, Shouta
AU - Sato, Shinichi
AU - Usuda, Haruo
AU - Saito, Masatoshi
AU - Kemp, Matthew W.
AU - Kobayashi, Yoshiyasu
N1 - Publisher Copyright:
© 2020 Japan Pediatric Society
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: Arginine vasopressin (AVP) infusion has been shown to be a useful strategy for the management of systemic perfusion failure in premature infants. Our objective was to determine the characteristics of the blood flow redistribution induced by AVP infusion in premature fetal sheep. Methods: Nine sheep fetuses at 99 to 113 days of gestation were continuously infused with AVP. Measurement of blood flow to individual fetal organs was performed using a colored microsphere technique, with measurements performed at 30 min before and 90 min after the initiation of AVP infusions. Results: The AVP infusion significantly increased blood flow to the medulla oblongata (P < 0.05), and significantly decreased flow to the adrenal glands (from 492.0 ± 239.6 to 364.9 ± 143.3 mL/min/100 g, P < 0.05) and heart (from 592.6 ± 184.5 to 435.6 ± 137.4 mL/min/100 g, P < 0.05). The infusion significantly increased the vascular resistance in adrenal glands, kidneys, ileum, colon, heart, and cerebellum. In the brain, except for the cerebellum, no significant increase in resistance was identified. Conclusions: There was no significant response to AVP infusion in cerebral blood flow in mid-gestation fetal sheep. Our observations suggest that, under AVP stimulation, the blood flow to the adrenal glands and myocardium might be decreased due to an increase in vascular resistance.
AB - Background: Arginine vasopressin (AVP) infusion has been shown to be a useful strategy for the management of systemic perfusion failure in premature infants. Our objective was to determine the characteristics of the blood flow redistribution induced by AVP infusion in premature fetal sheep. Methods: Nine sheep fetuses at 99 to 113 days of gestation were continuously infused with AVP. Measurement of blood flow to individual fetal organs was performed using a colored microsphere technique, with measurements performed at 30 min before and 90 min after the initiation of AVP infusions. Results: The AVP infusion significantly increased blood flow to the medulla oblongata (P < 0.05), and significantly decreased flow to the adrenal glands (from 492.0 ± 239.6 to 364.9 ± 143.3 mL/min/100 g, P < 0.05) and heart (from 592.6 ± 184.5 to 435.6 ± 137.4 mL/min/100 g, P < 0.05). The infusion significantly increased the vascular resistance in adrenal glands, kidneys, ileum, colon, heart, and cerebellum. In the brain, except for the cerebellum, no significant increase in resistance was identified. Conclusions: There was no significant response to AVP infusion in cerebral blood flow in mid-gestation fetal sheep. Our observations suggest that, under AVP stimulation, the blood flow to the adrenal glands and myocardium might be decreased due to an increase in vascular resistance.
KW - arginine vasopressin
KW - microspheres
KW - premature infant
KW - sheep
KW - vascular resistance
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U2 - 10.1111/ped.14141
DO - 10.1111/ped.14141
M3 - Article
C2 - 31916650
AN - SCOPUS:85085709425
VL - 62
SP - 688
EP - 693
JO - Pediatrics International
JF - Pediatrics International
SN - 1328-8067
IS - 6
ER -