TY - JOUR
T1 - Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor
T2 - A case report
AU - Suzuki, Satoko
AU - Takayama, Shin
AU - Kikuchi, Akiko
AU - Arita, Ryutaro
AU - Abe, Michiaki
AU - Saito, Ryuta
AU - Kanamori, Masayuki
AU - Tominaga, Teiji
AU - Ishii, Tadashi
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Introduction:: Anaplastic astrocytoma has a dismal prognosis with conventional treatment. Multidisciplinary treatment is needed to control the disease; however, side effects of the treatment reduce a patient's quality of life (QOL). Carmustine-impregnated wafers (Gliadel®, Eisai Co., Ltd., Tokyo, Japan), one of the treatment modalities for anaplastic astrocytoma, has been reported to have drug-induced fever as a side effect. Case Report:: A 36-year-old man underwent excision for a recurrent brain tumor. Histopathological examination established a diagnosis of anaplastic astrocytoma and an intracranial carmustine implant was placed for local chemotherapy. Postoperatively, the patient developed high fever, which could not be controlled using antipyretics. The high fever ameliorated dramatically after the administration of Kampo medicines, specifically orengedokuto and shosaikoto, and the patient could continue chemotherapy. Conclusion:: To the best of our knowledge, this is the first report of successful treatment of intractable carmustine implant-induced fever using Kampo medicine. In this case, Kampo medicine led to an improvement of QOL.
AB - Introduction:: Anaplastic astrocytoma has a dismal prognosis with conventional treatment. Multidisciplinary treatment is needed to control the disease; however, side effects of the treatment reduce a patient's quality of life (QOL). Carmustine-impregnated wafers (Gliadel®, Eisai Co., Ltd., Tokyo, Japan), one of the treatment modalities for anaplastic astrocytoma, has been reported to have drug-induced fever as a side effect. Case Report:: A 36-year-old man underwent excision for a recurrent brain tumor. Histopathological examination established a diagnosis of anaplastic astrocytoma and an intracranial carmustine implant was placed for local chemotherapy. Postoperatively, the patient developed high fever, which could not be controlled using antipyretics. The high fever ameliorated dramatically after the administration of Kampo medicines, specifically orengedokuto and shosaikoto, and the patient could continue chemotherapy. Conclusion:: To the best of our knowledge, this is the first report of successful treatment of intractable carmustine implant-induced fever using Kampo medicine. In this case, Kampo medicine led to an improvement of QOL.
KW - Anaplastic astrocytoma
KW - Carmustine
KW - Drug-induced fever
KW - Kampo
KW - Orengedokuto
KW - Shosaikoto
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U2 - 10.1016/j.explore.2020.08.014
DO - 10.1016/j.explore.2020.08.014
M3 - Article
C2 - 32900615
AN - SCOPUS:85090303272
VL - 17
SP - 236
EP - 238
JO - Explore: The Journal of Science and Healing
JF - Explore: The Journal of Science and Healing
SN - 1550-8307
IS - 3
ER -