Abstract
The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.
Original language | English |
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Pages (from-to) | 69-80 |
Number of pages | 12 |
Journal | Nature Reviews Immunology |
Volume | 14 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2014 Feb |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology