Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Marcus R. Clark, Malay Mandal, Kyoko Ochiai, Harinder Singh

Research output: Contribution to journalReview articlepeer-review

166 Citations (Scopus)

Abstract

The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalNature Reviews Immunology
Volume14
Issue number2
DOIs
Publication statusPublished - 2014 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling'. Together they form a unique fingerprint.

Cite this