Orbital tumor diagnosis by positron emission tomography using 18F-fluorodeoxyuridine

Motohiro Kiyosawa, Katsuyoshi Mizuno, Kiichi Ishiwata, Shoichi Watanuki, Minoru Monma, Tatsuo Ido, Yoshinao Abe, Hiroshi Fukuda, Taiju Matsuzawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The distribution of 18F-labeled 5-fluoro-2'-deoxyuridine (18F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with 18F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalOphthalmic Research
Volume18
Issue number5
DOIs
Publication statusPublished - 1986

Keywords

  • Aseptic inflammation
  • F-fluorodeoxyuridine
  • Malignant tumor
  • Orbital tumor diagnosis
  • Positron emission tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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