Abstract
The distribution of 18F-labeled 5-fluoro-2'-deoxyuridine (18F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with 18F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.
Original language | English |
---|---|
Pages (from-to) | 292-298 |
Number of pages | 7 |
Journal | Ophthalmic Research |
Volume | 18 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1986 |
Keywords
- Aseptic inflammation
- F-fluorodeoxyuridine
- Malignant tumor
- Orbital tumor diagnosis
- Positron emission tomography
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience