Orbital tumor diagnosis by positron emission tomography using 18F-fluorodeoxyuridine

Motohiro Kiyosawa; Katsuyoshi Mizuno; Kiichi Ishiwata; Shoichi Watanuki; Minoru Monma; Tatsuo Ido; Yoshinao Abe; Hiroshi Fukuda; Taiju Matsuzawa

doi:10.1159/000265451

Orbital tumor diagnosis by positron emission tomography using ¹⁸F-fluorodeoxyuridine

Motohiro Kiyosawa, Katsuyoshi Mizuno, Kiichi Ishiwata, Shoichi Watanuki, Minoru Monma, Tatsuo Ido, Yoshinao Abe, Hiroshi Fukuda, Taiju Matsuzawa

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The distribution of ¹⁸F-labeled 5-fluoro-2'-deoxyuridine (¹⁸F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with ¹⁸F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.

Original language	English
Pages (from-to)	292-298
Number of pages	7
Journal	Ophthalmic Research
Volume	18
Issue number	5
DOIs	https://doi.org/10.1159/000265451
Publication status	Published - 1986

Keywords

Aseptic inflammation
F-fluorodeoxyuridine
Malignant tumor
Orbital tumor diagnosis
Positron emission tomography

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1159/000265451

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title = "Orbital tumor diagnosis by positron emission tomography using 18F-fluorodeoxyuridine",

abstract = "The distribution of 18F-labeled 5-fluoro-2'-deoxyuridine (18F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with 18F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.",

keywords = "Aseptic inflammation, F-fluorodeoxyuridine, Malignant tumor, Orbital tumor diagnosis, Positron emission tomography",

author = "Motohiro Kiyosawa and Katsuyoshi Mizuno and Kiichi Ishiwata and Shoichi Watanuki and Minoru Monma and Tatsuo Ido and Yoshinao Abe and Hiroshi Fukuda and Taiju Matsuzawa",

year = "1986",

doi = "10.1159/000265451",

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pages = "292--298",

journal = "Ophthalmic Research",

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T1 - Orbital tumor diagnosis by positron emission tomography using 18F-fluorodeoxyuridine

AU - Kiyosawa, Motohiro

AU - Mizuno, Katsuyoshi

AU - Ishiwata, Kiichi

AU - Watanuki, Shoichi

AU - Monma, Minoru

AU - Ido, Tatsuo

AU - Abe, Yoshinao

AU - Fukuda, Hiroshi

AU - Matsuzawa, Taiju

PY - 1986

Y1 - 1986

N2 - The distribution of 18F-labeled 5-fluoro-2'-deoxyuridine (18F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with 18F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.

AB - The distribution of 18F-labeled 5-fluoro-2'-deoxyuridine (18F-FdUrd) in orbital tissue, tumor and aseptic inflammation was examined in rats. The distribution in paraorbital structures, other than bone, was low. The tumor-to-organ ratios were sufficient for tumor imaging by positron emission tomography (PET). Positron emission tomography with 18F-FdUrd clearly showed the experimental orbital VX-2 tumor in rabbits. The difference between the experimental orbital tumor and croton oil-induced aseptic inflammation or a normal orbit was apparently established in the PET image with slow and fast clearance of radioactivity, respectively.

KW - Aseptic inflammation

KW - F-fluorodeoxyuridine

KW - Malignant tumor

KW - Orbital tumor diagnosis

KW - Positron emission tomography

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