Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice

Akira Asai, Takahisa Nakano, Masahiro Takahashi, Akihiko Nagao

Research output: Contribution to journalArticlepeer-review

130 Citations (Scopus)

Abstract

A series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates.

Original languageEnglish
Pages (from-to)7302-7306
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume53
Issue number18
DOIs
Publication statusPublished - 2005 Sep 7
Externally publishedYes

Keywords

  • Apocarotenoid
  • Carotenoid
  • Crocetin
  • Crocin
  • Crocus sativus
  • Gardenia jasminoides
  • Glucuronide
  • Intestinal absorption
  • Mouse

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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