Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms

Takeyuki Tada, Masashi Shin, Hidefumi Fukushima, Koji Okabe, Satoru Ozeki, Masato Okamoto, Eijiro Jimi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Oral squamous cell carcinoma (SCC) cells frequently invade mandibular bone, and bone invasion is a common clinical problem. Recent studies have revealed that bone resorption by osteoclasts is an important step in the progress of bone invasion by oral SCCs. We previously reported that oral SCC cells induce osteoclastogenesis by suppressing osteoprotegerin (OPG) in host cells. In the present study, we examined the effects of oral SCCs on osteoclast function. Both BHY cells, a human oral SCC cell line, and its conditioned medium (BHY-CM) stimulated osteoclast survival by suppressing Bim, a pro-apoptotic protein, depending on extracellular signal-regulated kinase (ERK) and multinucleation. Adding BHY cells but not BHY-CM induced pit-forming activity by osteoclasts and adding OPG abrogated the activity. Thus, oral SCC cells regulate not only osteoclastogenesis but also its function.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalCancer Letters
Volume274
Issue number1
DOIs
Publication statusPublished - 2009 Feb 8

Keywords

  • Bone invasion
  • Oral squamous cell carcinoma
  • Osteoclasts
  • RANKL

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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