Oral Recombinant Methioninase, Combined with Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma

Takashi Higuchi, Hiromichi Oshiro, Kentaro Miyake, Norihiko Sugisawa, Qinghong Han, Yuying Tan, Junho Park, Zhiying Zhang, Sahar Razmjooei, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Michael Bouvet, Sant P. Chawla, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman

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