Oral high dose 1,25(OH)2D3 pulse therapy

Mitsunobu Matsubara, Hisako Sugai, Yoshio Taguma, Kazuyuki Suzuki, Makoto Ishizaki, Hisashi Takahashi

Research output: Contribution to journalArticle

Abstract

To 13 uremic patients with secondary hyperparathyroidism, 4μg of 1,25 (OH) 2D3 were given orally twice a week for 4 weeks. Intact PTH values fell from 488.3±84.2 to 235.2 ±59.6pg/ml (Mean±SE, p<0.01), while serum total and ionized calcium elevated from 10.3 + 0.2 to 11.8±0.6mg/dl (p<0.01), from 1.43±0.03 to 1.64±0.06 mmol/1 (p<0.05), respectively, in 9 patients whose initial intact PTH level had been below 1000 pg/ml. The other 4 patients, of whom intact PTH level had been above 1000 pg/ml, did not show significant change in intact PTH values, though serum ionized calcium elevated slightly after this treatment. The correlation curve, determined by ionized calcium and intact PTH values in each period, was found to shift in only 2 out of 5. During the 4 weeks of high dose oral l,25(OH)2D3 therapy, mean blood pressure elevated from 92.4±3.3 to 103.5±3.5 mmHg (p<0.01) in general, and 7 patients out of 13 complained of mental irritability. These data suggest that oral administration of high dose 1,25 (OH) 2D3 suppresses PTH secretion of uremic patients directly, however, reliability of this effect is still controversial Indication of this therapy and adverse effects caused by rapid increase in serum calcium should be studied in more detail.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalThe Japanese Journal Of Nephrology
Volume33
Issue number2
DOIs
Publication statusPublished - 1991 Jan
Externally publishedYes

Keywords

  • 25(OH)2D3 pulse therapy
  • direct PTH suppression
  • intact PTH
  • ionized calcium
  • oral 1

ASJC Scopus subject areas

  • Nephrology

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    Matsubara, M., Sugai, H., Taguma, Y., Suzuki, K., Ishizaki, M., & Takahashi, H. (1991). Oral high dose 1,25(OH)2D3 pulse therapy. The Japanese Journal Of Nephrology, 33(2), 119-123. https://doi.org/10.14842/jpnjnephrol1959.33.119