Oral antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis isolates from Japanese children

Junichiro Nishi, Masao Yoshinaga, Koichi Tokuda, Kaori Masuda, Ryuji Masuda, Akira Kamenosono, Kunihiro Manago, Koichiro Miyata

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The minimum inhibitory concentrations (MICs) of 11 oral antibiotics were measured for 140 Streptococcus pneumoniae, 115 Haemophilus influenzae, and 46 Moraxella catarrhalis strains isolated from Japanese children. The antibiotics selected included a range of commonly prescribed agents together with a selection of new cefems and a penem. Cefditoren was most active against the highly penicillin resistant S. pneumoniae, β-lactamase-producing H. influenzae and β-lactamase-negative ampicillin-resistant H. influenzae. However, amoxycillin retained good activity against the penicillin-susceptible or -intermediately resistant S. pneumoniae (88.6%) and most of ampicillin-susceptible or -intermediately resistant H. influenzae (87.9%). We thus consider that amoxycillin remains a useful initial choice for the treatment of paediatric respiratory infections in Japan.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalInternational Journal of Antimicrobial Agents
Volume20
Issue number2
DOIs
Publication statusPublished - 2002 Aug 1
Externally publishedYes

Keywords

  • Haemophilus influenzae
  • Moraxella catarrhalis
  • Oral antibiotics
  • Streptococcus pneumoniae
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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