Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model

Noritoshi Takahashi, Haruki Kitazawa, Noriyuki Iwabuchi, Jin Zhong Xiao, Kazuhiro Miyaji, Keiji Iwatsuki, Tadao Saito

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

We have reported the antiallergic activities of the immunostimulatory oligodeoxynucleotide (ODN) BL07S, identified from genomic DNA of Bifidobacterium longum BB536 from in vitro and in vivo studies. The present study evaluated the efficiency of ODN BL07S in preventing allergic responses by oral administration. Oral administration of BL07S suppressed serum ovalbumin (OVA)-specific immunoglobulin (Ig) E levels and improved the OVA-specific IgG2a/IgG1 ratio. ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics.

Original languageEnglish
Pages (from-to)2013-2017
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume70
Issue number8
DOIs
Publication statusPublished - 2006

Keywords

  • Allergy
  • Bifidobacterium longum BB536
  • Immunoglobulin (Ig) E
  • Immunostimulatory DNA
  • Probiotics

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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