TY - JOUR
T1 - Optimizing the host substrate environment for cardiac angiogenesis, arteriogenesis, and myogenesis
AU - Maeda, Kay
AU - Alarcon, Emilio I.
AU - Suuronen, Erik J.
AU - Ruel, Marc
N1 - Funding Information:
This work was supported by the Canadian Institute of Health Research (CIHR); Grant MOP-77536 to M Ruel and EJ Suuronen)
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - Introduction: The diseased host milieu, such as endothelial dysfunction (ED), decreased NO bioavailability, and ischemic/inflammatory post-MI environment, hamper the clinical success of existing cardiac regenerative therapies. Area covered: In this article, current strategies including pharmacological and nonpharmacological approaches for improving the diseased host milieu are reviewed. Specifically, the authors provide focus on: i) the mechanism of ED in patients with cardiovascular diseases, ii) the current results of ED improving strategies in pre-clinical and clinical studies, and iii) the use of biomaterials as a novel modulator in damaged post-MI environment. Expert opinion: Adjunct therapies which improve host endothelial function have demonstrated promising outcomes, potentially overcoming disappointing results of cell therapy in human studies. In the future, elucidation of the interactions between the host tissue and therapeutic agents, as well as downstream signaling pathways, will be the next challenges in enhancing regenerative therapy. More careful investigations are also required to establish these agents’ safety and efficacy for wide usage in humans.
AB - Introduction: The diseased host milieu, such as endothelial dysfunction (ED), decreased NO bioavailability, and ischemic/inflammatory post-MI environment, hamper the clinical success of existing cardiac regenerative therapies. Area covered: In this article, current strategies including pharmacological and nonpharmacological approaches for improving the diseased host milieu are reviewed. Specifically, the authors provide focus on: i) the mechanism of ED in patients with cardiovascular diseases, ii) the current results of ED improving strategies in pre-clinical and clinical studies, and iii) the use of biomaterials as a novel modulator in damaged post-MI environment. Expert opinion: Adjunct therapies which improve host endothelial function have demonstrated promising outcomes, potentially overcoming disappointing results of cell therapy in human studies. In the future, elucidation of the interactions between the host tissue and therapeutic agents, as well as downstream signaling pathways, will be the next challenges in enhancing regenerative therapy. More careful investigations are also required to establish these agents’ safety and efficacy for wide usage in humans.
KW - Angiogenesis
KW - arteriogenesis
KW - cardiovascular disease
KW - cell therapy
KW - endothelial dysfunction
KW - myogenesis
KW - tissue engineering
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U2 - 10.1080/14712598.2017.1293038
DO - 10.1080/14712598.2017.1293038
M3 - Review article
C2 - 28274146
AN - SCOPUS:85014855100
VL - 17
SP - 435
EP - 447
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
SN - 1471-2598
IS - 4
ER -