Optimization of [11C]HCN production and no-carrier-added [1-11C]amino acid synthesis

Ren Iwata, Tatsuo Ido, Toshihiro Takahashi, Hiroaki Nakanishi, Shigenori Iida

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    60 Citations (Scopus)

    Abstract

    The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration of 5 vol%, a Pt furnace temperature of 920°C, and a reaction gas flow rate of over 200 mL/min. Absorbers were used to remove O2 and H2O from the reaction gas. The synthesis of no-carrier-added [1-11C]amino acids from [11C]HCN via [11C]aminonitriles was successfully carried out. This method is suitable for automation of [1-11C]amino acid production.

    Original languageEnglish
    Pages (from-to)97-102
    Number of pages6
    JournalInternational Journal of Radiation Applications and Instrumentation. Part
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - 1987

    ASJC Scopus subject areas

    • Radiation
    • Engineering(all)

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