Optimization of [11C]HCN production and no-carrier-added [1-11C]amino acid synthesis

Ren Iwata, Tatsuo Ido, Toshihiro Takahashi, Hiroaki Nakanishi, Shigenori Iida

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration of 5 vol%, a Pt furnace temperature of 920°C, and a reaction gas flow rate of over 200 mL/min. Absorbers were used to remove O2 and H2O from the reaction gas. The synthesis of no-carrier-added [1-11C]amino acids from [11C]HCN via [11C]aminonitriles was successfully carried out. This method is suitable for automation of [1-11C]amino acid production.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume38
Issue number2
DOIs
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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