TY - JOUR
T1 - Optimization of [11C]HCN production and no-carrier-added [1-11C]amino acid synthesis
AU - Iwata, Ren
AU - Ido, Tatsuo
AU - Takahashi, Toshihiro
AU - Nakanishi, Hiroaki
AU - Iida, Shigenori
PY - 1987
Y1 - 1987
N2 - The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration of 5 vol%, a Pt furnace temperature of 920°C, and a reaction gas flow rate of over 200 mL/min. Absorbers were used to remove O2 and H2O from the reaction gas. The synthesis of no-carrier-added [1-11C]amino acids from [11C]HCN via [11C]aminonitriles was successfully carried out. This method is suitable for automation of [1-11C]amino acid production.
AB - The optimal conditions for the catalytic production of [11C]HCN from [11C]CO2 were investigated. [11C]CO2 was reduced to [11C]CH4 with H2 on Ni and then converted to [11C]HCN by reaction with NH3 on Pt in a radiochemical yield of more than 95% under the optimized conditions of an NH3 concentration of 5 vol%, a Pt furnace temperature of 920°C, and a reaction gas flow rate of over 200 mL/min. Absorbers were used to remove O2 and H2O from the reaction gas. The synthesis of no-carrier-added [1-11C]amino acids from [11C]HCN via [11C]aminonitriles was successfully carried out. This method is suitable for automation of [1-11C]amino acid production.
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U2 - 10.1016/0883-2889(87)90003-7
DO - 10.1016/0883-2889(87)90003-7
M3 - Article
C2 - 3032866
AN - SCOPUS:0023144672
SN - 0969-8043
VL - 38
SP - 97
EP - 102
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 2
ER -