Optimal selection method for establishing an inbred strain of laboratory animals with high performance for litter size at weaning

Masahiro Satoh, Kazuo Ishii

Research output: Contribution to journalArticle

Abstract

The optimal selection method was investigated for establishing an inbred strain of laboratory animals with high performance for litter size at weaning (LSW). A Monte Carlo computer simulation was used to assess the effects of our selection methods on the genetic change of LSW under the continuous use of full-sib mating for 20 generations. Smaller number of growing animals of each sex per litter and genetic evaluation for selection using a BLUP animal model increased LSW. Use of information on another trait genetically related to LSW, larger population size, and greater number of generations for random selection before starting full-sib mating were useful for establishing an inbred strain of laboratory animals with high performance for LSW. It was concluded that LSW can be increased by directional selection when establishing inbred strains.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalAnimal Science Journal
Volume79
Issue number2
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Keywords

  • Breeding plan
  • Inbred strain
  • Laboratory animals
  • Litter size at weaning
  • Selection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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