TY - JOUR
T1 - Optimal Rectification without Forward-Current Suppression by Biological Molecular Motor
AU - Nakayama, Yohei
AU - Toyabe, Shoichi
N1 - Funding Information:
We thank Eiro Muneyuki for technical assistance with the sample preparation. We appreciate the helpful discussions with Yuki Izumida and Tomoaki Okaniwa. This work was supported by JSPS KAKENHI (No. JP18H05427, No. JP19H01864).
Publisher Copyright:
© 2021 American Physical Society.
PY - 2021/5/20
Y1 - 2021/5/20
N2 - We experimentally show that biological molecular motor F1-ATPase (F1) implements an optimal rectification mechanism. The rectification mechanism hardly suppresses the synthesis of adenosine triphosphate by F1, which is F1's physiological role, while inhibiting the unfavorable hydrolysis of adenosine triphosphate. This optimal rectification contrasts highly with that of a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. Our detailed analysis of single-molecule trajectories demonstrates a novel but simple rectification mechanism of F1 with parallel landscapes and asymmetric transition rates.
AB - We experimentally show that biological molecular motor F1-ATPase (F1) implements an optimal rectification mechanism. The rectification mechanism hardly suppresses the synthesis of adenosine triphosphate by F1, which is F1's physiological role, while inhibiting the unfavorable hydrolysis of adenosine triphosphate. This optimal rectification contrasts highly with that of a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. Our detailed analysis of single-molecule trajectories demonstrates a novel but simple rectification mechanism of F1 with parallel landscapes and asymmetric transition rates.
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U2 - 10.1103/PhysRevLett.126.208101
DO - 10.1103/PhysRevLett.126.208101
M3 - Article
C2 - 34110213
AN - SCOPUS:85106552739
VL - 126
JO - Physical Review Letters
JF - Physical Review Letters
SN - 0031-9007
IS - 20
M1 - 208101
ER -