Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment

Hisashi Yamanaka, Riko Togashi, Masayuki Hakoda, Chihiro Terai, Sadao Kashiwazaki, Takashi Dan, Naoyuki Kamatani

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

To find an optimal range of urate concentrations wherein the risk of attacks during the initial 6 months of treatment is minimized, data from 350 gouty patients treated with antihyperuricemic drugs were retrospectively analyzed. We determined the optimal range of urate concentrations to be 4.6- 6.6 mg/dl. If urate concentrations were within this range, the risk ratio of an attack as opposed to outside of the range was 0.705 (95% confidence interval, 0.629-0.791). The increase (or decrease) in urate concentration in one month associated with minimal risk of gouty attacks was also determined. The lowest risk ratio of attack (0.451) occurred at a range of -0.1 to 0.6 mg/dl/month increase in urate concentrations (95% confidence interval, 0.310- 0.655). In conclusion, we propose that urate concentrations during the initial 6 months of antihyperuricemic therapy should be maintained within a range of 4.6-6.6 mg/dl, and reduction in the urate concentrations during treatment should be as slow as possible.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume431
Publication statusPublished - 1998 Jun 4
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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