Optical coherence tomography for the staging of tumor infiltration in superficial esophageal squamous cell carcinoma

Waku Hatta, Kaname Uno, Tomoyuki Koike, Satoshi Yokosawa, Katsunori Iijima, Akira Imatani, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Background: Optical coherence tomography (OCT) is a noninvasive technology that can produce high-resolution cross-sectional images in real-time without acoustic coupling, enabling precise assessment of tumor invasion in superficial esophageal squamous cell carcinomas (SESCCs). Objective: To elucidate the usefulness of in vivo OCT for the staging of SESCCs. Design: A single-center, prospective study in 2 phases: phase I to establish the OCT criteria classified into 3 categories (epithelium or lamina propria mucosa [EP/LPM], muscularis mucosa [MM], submucosa [SM]) and phase II to evaluate these criteria. Setting: An academic medical center. Patients: Sixty-two patients with a histological diagnosis of SESCC by routine endoscopy. In the phase I study, 35 images from 16 patients were used. In the phase II study, 109 images from 46 subsequent consecutive patients enrolled from January 2007 to May 2009 were used. Interventions: We performed OCT for preoperative staging followed by endoscopic submucosal dissection or a surgical procedure and compared precisely the visualized OCT sites with the corresponding tissue sections. Main Outcome Measurements: The accuracy of OCT for the staging. Results: The overall accuracy rate was 92.7% (EP/LPM, 94.9%; MM, 85.0%; SM, 90.9%). The OCT signal penetration depth was sufficient to depict the boundary of the deepest region of cancer, the thickness of which was less than 1.5 mm. Limitations: The small number of patients. Conclusions: To our knowledge, this is the first study demonstrating that OCT might be useful for the preoperative staging of SESCCs with a high degree of accuracy.

Original languageEnglish
Pages (from-to)899-906
Number of pages8
JournalGastrointestinal Endoscopy
Volume71
Issue number6
DOIs
Publication statusPublished - 2010 May

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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