Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric Glaucoma

Yukihiro Shiga, Hiroshi Kunikata, Naoko Aizawa, Naoki Kiyota, Yukiko Maiya, Yu Yokoyama, Kazuko Omodaka, Hidetoshi Takahashi, Tomoki Yasui, Keiichi Kato, Aiko Iwase, Toru Nakazawa

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Purpose: To compare optic nerve head (ONH) blood flow in healthy eyes, eyes with preperimetric glaucoma (PPG), and eyes with mild normal-tension glaucoma (NTG) using laser speckle flowgraphy (LSFG).Methods: In 172 eyes (normal: 44 eyes; PPG: 62 eyes; mild NTG: 66 eyes), LSFG was used to measure mean blur rate in the ONH tissue area (MBRT), an index of capillary blood flow. Multiple regression analysis was performed to determine factors affecting circumpapillary retinal nerve fiber layer thickness (cpRNFLT), mean deviation (MD) and pattern standard deviation (PSD) of the visual field.Results: Despite similar characteristics in age, refractive error and systemic variables among the study groups, MBRT in the normal eyes differed significantly from both the PPG and mild NTG eyes (P = 0.001, P < 0.001, respectively). Multiple regression analysis revealed that MBRT was an independent factor affecting cpRNFLT, MD and PSD (P < 0.001, P = 0.001, P = 0.003, respectively).Conclusion: ONH blood flow was detectibly reduced in eyes with PPG, in close association with structural and visual field damage. This suggests that measuring ONH tissue-area blood flow with LSFG may be a useful way of monitoring glaucoma severity, even in the early stages of glaucoma.

Original languageEnglish
Pages (from-to)1447-1453
Number of pages7
JournalCurrent Eye Research
Volume41
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • Laser speckle flowgraphy
  • glaucoma
  • ocular blood flow
  • optic nerve head
  • preperimetric glaucoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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