Opercular to interhemispheric source distribution of benign rolandic spikes of childhood

Mamiko Ishitobi, Nobukazu Nakasato, Katsuya Yamamoto, Kazuie Iinuma

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

We evaluated the source distribution of benign rolandic spikes of childhood along and across the central sulcus in 15 patients, aged between 7 and 15 years, who suffered from seizure disorders. Previous routine EEG showed centrotemporal spikes, but none of them had major abnormalities on brain magnetic resonance imaging or neurological deficits. The equivalent current dipoles (ECDs) of the spikes measured by whole-head magnetoencephalography (MEG) were compared to the spike distributions detected by simultaneous scalp EEG according to the international 10-20 system. Locations and orientations of the MEG spikes corresponded to the EEG spike distribution as follows: superiorly oriented spike MEG dipoles in the opercular area corresponded to T3/4 negative peaks (8 spike groups in 6 patients); anteriorly oriented spike dipoles in the rolandic area corresponded to C3/4 or P3/4 negative peaks (17 spike groups in 13 patients); laterally oriented spike dipoles in the interhemispheric area corresponded to Cz/Pz negative peaks (4 spike groups in 3 patients); and others (4 spike groups in 4 patients). Rolandic spikes include three main types according to the ECD location from the opercular to the interhemispheric areas. The functional anatomy of benign rolandic spikes was correlated with partial seizure semiology. All three rolandic spike types can be explained by a precentral origin, assuming that the surface negative potential is continuous from the gyral to fissural cortices.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalNeuroImage
Volume25
Issue number2
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

Keywords

  • Centrotemporal spike
  • Electroencephalography
  • Magnetoencephalography
  • Midline spike
  • Rolandic epilepsy

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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