Open-loop Analysis of Transfer Characteristics from Blood Pressure to Heart Rate Using an Effectively Total Artificial Heart

Akira Tanaka, Makoto Yoshizawa, Ken Ichi Abe, Hiroshi Takeda, Tomoyuki Yambe, Shin Ichi Nitta, Yusuke Abe, Tsuneo Chinzei, Kou Imachi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


It is desirable for the dynamic behavior of the drive rate of the artificial heart to be as similar as possible to that of the recipient's heart rate (HR) before implantation. This requires a model which can simulate the behavior of HR on the basis of only the information measured with the limited number of approvable implanted sensors. This article provides a linear time series model for explaining the behavior of HR only with aortic pressure and right atrial pressure. This could be obtained from open-loop analysis using a total artificial heart, which was introduced for measuring HR in vivo and for eliminating its effect on blood pressure. The model was identified in a goat equipped with a special biventricular assist device called the effectively total artificial heart (ETAH). The ETAH was introduced to make an open loop and awake situation in the animal with almost intact autonomic nerves, which could enhance the accuracy and reliability of the identification of the model. The adequacy of the proposed model was ascertained in several data sets measured in two goats, which were different from the data set used for identification. Most of the mean estimation errors were less than 3 beats/min and auto-correlation analysis showed approvable statistical appropriateness. However, it was clarified through comparison with the 1/R control method that the proposed model has a few problems still to be solved before its future implementation as an automatic controller of the TAH.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalArtificial Organs
Issue number1
Publication statusPublished - 2004 Jan


  • Autoregressive exogenous model
  • Heart rate variability
  • Peripheral vascular resistance
  • System identification
  • Total artificial heart

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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