Open-label study of cognitive behavioural therapy for individuals with at-risk mental state: Feasibility in the Japanese clinical setting

Kazunori Matsumoto, Noriyuki Ohmuro, Naohisa Tsujino, Shimako Nishiyama, Koichi Abe, Yumiko Hamaie, Masahiro Katsura, Naomi Inoue, Hiroo Matsuoka, Yasuhiro Kawasaki, Toshifumi Kishimoto, Michio Suzuki, Masafumi Mizuno

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aim: To date, most cognitive behavioural therapy (CBT) trials for individuals with at-risk metal state (ARMS) have been conducted in few Western countries and its feasibility in other regions, including Japan, has not been established. Methods: We designed an open-label pilot study. Fourteen ARMS participants received CBT over 6 months and were followed-up for 6 months. Results: Thirteen individuals completed the CBT intervention and assessments. The mean total score on the Positive and Negative Syndrome Scale improved from 60.2 to 46.0 after the intervention (Cohen's d = 1.1). The effects were maintained at the follow-up assessment. One participant transitioned to psychosis after the CBT intervention, and was the only patient who received antipsychotics. Conclusions: We confirmed the feasibility of the provision of CBT for ARMS in Japan. Since overprescription of antipsychotics is a matter of great concern in Japan, CBT could be a valuable alternative treatment strategy.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalEarly Intervention in Psychiatry
Volume13
Issue number1
DOIs
Publication statusPublished - 2019 Feb 1

Keywords

  • at-risk mental state
  • cognitive behavioural therapy
  • early intervention
  • psychological treatment
  • psychosis

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Psychiatry and Mental health
  • Biological Psychiatry

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