Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection

Gembu Abe, Shu Hua Lee, Ing Jia Li, Chun Ju Chang, Koji Tamura, Kinya G. Ota

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Twin-tail goldfish strains are examples of drastic morphological alterations that emerged through domestication. Although this mutation is known to be caused by deficiency of one of two duplicated chordin genes, it is unknown why equivalent mutations have not been observed in other domesticated fish species. Here, we compared the chordin gene morphant phenotypes of single-tail goldfish and common carp (close relatives, both of which underwent chordin gene duplication and domestication). Morpholino-induced knockdown depleted chordin gene expression in both species; however, while knockdown reproduced twin-tail morphology in single-tail goldfish, it had no effect on common carp morphology. This difference can be explained by the observation that expression patterns of the duplicated chordin genes overlap completely in common carp, but are sub-functionalized in goldfish. Our finding implies that goldfish drastic morphological changes might be enhanced by the subsequent occurrence of three different types of evolutionary event (duplication, sub-functionalization, and selection) in a certain order.

    Original languageEnglish
    Article number26838
    JournalScientific reports
    Volume6
    DOIs
    Publication statusPublished - 2016 May 25

    ASJC Scopus subject areas

    • General

    Fingerprint Dive into the research topics of 'Open and closed evolutionary paths for drastic morphological changes, involving serial gene duplication, sub-functionalization, and selection'. Together they form a unique fingerprint.

    Cite this