During the prenatal development of the mouse tongue, the intralingual ganglion was investigated histo-chemically and immunohistochemically for acelylcholineslerase (AChE) activity, the capacity to take up L.-3.4-dihy-droxyphenylalaninc (L-DOPA) and vasoactive intestinal polypcptidc (VlP)-Hkc immunorcactivity. Ache-positive cells were first observed at gestational day 12, and Ache-positive neurons which take up L-DOPA were found at gestational day 14. while VIP-like immunoreactive neurons were not seen until gestational day 16. The present results suggested that the cholinergic neurons within the mouse tongue can take up /.-DOPA from gestational day 14 and synthesize VIP from gcstalional day 16.
- Intralingual ganglion
- Vasoactive intestinal polypeptide
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